Amitriptyline; chlordiazepoxide major concurrent use of intramuscular olanzapine and parenteral benzodiazepines is not recommended due to the potential for adverse effects from the combination, including excess sedation and or cardiopulmonary depression.
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olanzapine administered with lithium or valproate resulted in increased levels 10 of tremor, dry mouth, increased appetite, and weight gain.
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the incidence of somnolence during the 24 hour im treatment period in clinical trials in agitated patients with schizophrenia or bipolar i mania was 6 for intramuscular olanzapine for injection and 3 for placebo.
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in a 12-month recurrence prevention study in manic episode patients who achieved remission on olanzapine and were then randomised to olanzapine or placebo, olanzapine demonstrated statistically significant superiority over placebo on the primary endpoint of bipolar recurrence.
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