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xeloda, 1250 mg m2 twice daily for 14 days followed by a 1-week rest, was selected for further clinical development based on the overall safety and efficacy profile of the three schedules studied.
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altogether, in both trials, 603 patients were randomized to treatment with xeloda at a dose of 1250 mg m 2 twice daily for 2 weeks followed by a 1-week rest period and given as 3-week cycles; 604 patients were randomized to treatment with 5-fu and leucovorin 20 mg m 2 leucovorin iv followed by 425 mg m 2 iv bolus 5-fu, on days 1 to 5, every 28 days .
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